This increases people's risk of contracting or transmitting HIV/AIDS or hepatitis. In addition, because MDMA can promote trust and closeness, its use-especially combined with sildenafil (Viagra ®)-may encourage unsafe sexual behavior. This can lead to a spike in body temperature that can occasionally result in liver, kidney, or heart failure or even death. High doses of MDMA can affect the body’s ability to regulate temperature. It's possible that some of these effects may be due to the combined use of MDMA with other drugs, especially marijuana. decreased interest in and pleasure from sex.Over the course of the week following moderate use of the drug, a person may experience: MDMA's effects last about 3 to 6 hours, although many users take a second dose as the effects of the first dose begin to fade. Photo by ©Jochen Schoenfield/Shutterstock The release of large amounts of serotonin likely causes the emotional closeness, elevated mood, and empathy felt by those who use MDMA. It also triggers hormones that affect sexual arousal and trust. Serotonin-affects mood, appetite, sleep, and other functions.Norepinephrine-increases heart rate and blood pressure, which are particularly risky for people with heart and blood vessel problems.Dopamine-produces increased energy/activity and acts in the reward system to reinforce behaviors.MDMA increases the activity of three brain chemicals: Some people take MDMA in combination with other drugs such as alcohol or marijuana. However, people who purchase powder or capsules sold as Molly often actually get other drugs such as synthetic cathinones ("bath salts") instead (see " Added Risk of MDMA"). The popular nickname Molly (slang for "molecular") often refers to the supposedly "pure" crystalline powder form of MDMA, usually sold in capsules. People who use MDMA usually take it as a capsule or tablet, though some swallow it in liquid form or snort the powder.
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